Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B5a46da847041dedcf6c7777156774b8f> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B5a46da847041dedcf6c7777156774b8f NCIT_P378 "NCI" @default.
- B5a46da847041dedcf6c7777156774b8f type Axiom @default.
- B5a46da847041dedcf6c7777156774b8f annotatedProperty IAO_0000115 @default.
- B5a46da847041dedcf6c7777156774b8f annotatedSource NCIT_C65308 @default.
- B5a46da847041dedcf6c7777156774b8f annotatedTarget "A synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent." @default.