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- B5a53338d15a4f3929af2a45abb135261 NCIT_P378 "NCI" @default.
- B5a53338d15a4f3929af2a45abb135261 type Axiom @default.
- B5a53338d15a4f3929af2a45abb135261 annotatedProperty IAO_0000115 @default.
- B5a53338d15a4f3929af2a45abb135261 annotatedSource NCIT_C103194 @default.
- B5a53338d15a4f3929af2a45abb135261 annotatedTarget "A monoclonal antibody directed against B7H1 (B7 homolog 1; programmed cell death ligand 1) with potential immunostimulating activity. Upon intravenous administration, durvalumab binds to the cell surface antigen B7H1, thereby blocking B7H1 signaling. This may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against B7H1-expressing tumor cells. B7H1, a member of the B7 protein superfamily and a negative regulator of cytokine synthesis, is overexpressed on certain tumor cell types." @default.