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- B5a622eaa0593fca7b8c5a3c1bfda508c NCIT_P378 "NCI" @default.
- B5a622eaa0593fca7b8c5a3c1bfda508c type Axiom @default.
- B5a622eaa0593fca7b8c5a3c1bfda508c annotatedProperty IAO_0000115 @default.
- B5a622eaa0593fca7b8c5a3c1bfda508c annotatedSource NCIT_C61846 @default.
- B5a622eaa0593fca7b8c5a3c1bfda508c annotatedTarget "A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS)." @default.