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- B5aaea6077b522b30e5bfc9276dd1ecf3 NCIT_P378 "NCI" @default.
- B5aaea6077b522b30e5bfc9276dd1ecf3 type Axiom @default.
- B5aaea6077b522b30e5bfc9276dd1ecf3 annotatedProperty IAO_0000115 @default.
- B5aaea6077b522b30e5bfc9276dd1ecf3 annotatedSource NCIT_C1524 @default.
- B5aaea6077b522b30e5bfc9276dd1ecf3 annotatedTarget "The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis." @default.