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- B5b09181db2fd21b6b8bdde68b9f1b18d NCIT_P378 "NCI" @default.
- B5b09181db2fd21b6b8bdde68b9f1b18d type Axiom @default.
- B5b09181db2fd21b6b8bdde68b9f1b18d annotatedProperty IAO_0000115 @default.
- B5b09181db2fd21b6b8bdde68b9f1b18d annotatedSource NCIT_C230 @default.
- B5b09181db2fd21b6b8bdde68b9f1b18d annotatedTarget "The sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria." @default.