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- B5b1afcaf8bfdbfb09fde24a26f17cfab NCIT_P378 "NCI" @default.
- B5b1afcaf8bfdbfb09fde24a26f17cfab type Axiom @default.
- B5b1afcaf8bfdbfb09fde24a26f17cfab annotatedProperty IAO_0000115 @default.
- B5b1afcaf8bfdbfb09fde24a26f17cfab annotatedSource NCIT_C47622 @default.
- B5b1afcaf8bfdbfb09fde24a26f17cfab annotatedTarget "The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes." @default.