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- B5b3cdcb2e1dc996d1306dace567c17f9 NCIT_P378 "NCI" @default.
- B5b3cdcb2e1dc996d1306dace567c17f9 type Axiom @default.
- B5b3cdcb2e1dc996d1306dace567c17f9 annotatedProperty IAO_0000115 @default.
- B5b3cdcb2e1dc996d1306dace567c17f9 annotatedSource NCIT_C131909 @default.
- B5b3cdcb2e1dc996d1306dace567c17f9 annotatedTarget "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.