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- B5b55c29a47a8b1b41244a675dbdf45e8 NCIT_P378 "NCI" @default.
- B5b55c29a47a8b1b41244a675dbdf45e8 type Axiom @default.
- B5b55c29a47a8b1b41244a675dbdf45e8 annotatedProperty IAO_0000115 @default.
- B5b55c29a47a8b1b41244a675dbdf45e8 annotatedSource NCIT_C78856 @default.
- B5b55c29a47a8b1b41244a675dbdf45e8 annotatedTarget "An inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTOR phosphorylates transcription factors, such as S6K1 and 4E-BP1, which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival." @default.