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- B5b786a323930701552ee46343c844934 NCIT_P378 "KEGG" @default.
- B5b786a323930701552ee46343c844934 type Axiom @default.
- B5b786a323930701552ee46343c844934 annotatedProperty NCIT_P325 @default.
- B5b786a323930701552ee46343c844934 annotatedSource NCIT_C91520 @default.
- B5b786a323930701552ee46343c844934 annotatedTarget "The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes." @default.