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- B5c27dec1acf4740912643de1872b4a8a NCIT_P378 "NCI" @default.
- B5c27dec1acf4740912643de1872b4a8a type Axiom @default.
- B5c27dec1acf4740912643de1872b4a8a annotatedProperty IAO_0000115 @default.
- B5c27dec1acf4740912643de1872b4a8a annotatedSource NCIT_C61685 @default.
- B5c27dec1acf4740912643de1872b4a8a annotatedTarget "A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption." @default.