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- B5cee88f417885f60647eb9cb2e63b44a NCIT_P378 "NCI" @default.
- B5cee88f417885f60647eb9cb2e63b44a type Axiom @default.
- B5cee88f417885f60647eb9cb2e63b44a annotatedProperty IAO_0000115 @default.
- B5cee88f417885f60647eb9cb2e63b44a annotatedSource NCIT_C2656 @default.
- B5cee88f417885f60647eb9cb2e63b44a annotatedTarget "The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases." @default.