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- B5d0fef248b5e5764ae551f84b48bf2f2 NCIT_P378 "NCI" @default.
- B5d0fef248b5e5764ae551f84b48bf2f2 type Axiom @default.
- B5d0fef248b5e5764ae551f84b48bf2f2 annotatedProperty IAO_0000115 @default.
- B5d0fef248b5e5764ae551f84b48bf2f2 annotatedSource NCIT_C65761 @default.
- B5d0fef248b5e5764ae551f84b48bf2f2 annotatedTarget "A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow." @default.