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- B5d90865c3eb17dec50fbba36f7ee25d8 NCIT_P378 "NCI" @default.
- B5d90865c3eb17dec50fbba36f7ee25d8 type Axiom @default.
- B5d90865c3eb17dec50fbba36f7ee25d8 annotatedProperty IAO_0000115 @default.
- B5d90865c3eb17dec50fbba36f7ee25d8 annotatedSource NCIT_C84868 @default.
- B5d90865c3eb17dec50fbba36f7ee25d8 annotatedTarget "A ghrelin peptide analogue with potential anti-cachexia activity. Upon subcutaneous administration, ghrelin peptide analogue binds to and stimulates the G protein-coupled growth hormone secretagogue receptor (GHSR) in the central nervous system (CNS), thereby mimicking the appetite-stimulating and growth hormone-releasing effects of endogenous ghrelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play direct roles in cancer-related loss of appetite. Ghrelin, naturally secreted by gastric endocrine cells, is a 28 amino acid peptide and an endogenous ligand for GHSR." @default.