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- B5da357390897d55c8549c2d4852e545d NCIT_P378 "NCI" @default.
- B5da357390897d55c8549c2d4852e545d type Axiom @default.
- B5da357390897d55c8549c2d4852e545d annotatedProperty IAO_0000115 @default.
- B5da357390897d55c8549c2d4852e545d annotatedSource NCIT_C150507 @default.
- B5da357390897d55c8549c2d4852e545d annotatedTarget "A mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins), with potential antineoplastic activity. Upon administration, Smac mimetic BI 891065 targets and binds to the Smac binding groove on IAPs, including the caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting certain caspases." @default.