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- B5fa7385c1f07f68fdd6fca20fbda718f NCIT_P378 "NCI" @default.
- B5fa7385c1f07f68fdd6fca20fbda718f type Axiom @default.
- B5fa7385c1f07f68fdd6fca20fbda718f annotatedProperty IAO_0000115 @default.
- B5fa7385c1f07f68fdd6fca20fbda718f annotatedSource NCIT_C96040 @default.
- B5fa7385c1f07f68fdd6fca20fbda718f annotatedTarget "An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), anti-OX40 monoclonal antibody selectively binds to and activates the OX40 receptor. Receptor activation induces proliferation of memory and effector T lymphocytes. In the presence of tumor associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed by CD4 T cells and provides a costimulatory signal for T cell activation." @default.