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- B5fc2e6d4aecf2c1b186e68b965bbf466 NCIT_P378 "NCI" @default.
- B5fc2e6d4aecf2c1b186e68b965bbf466 type Axiom @default.
- B5fc2e6d4aecf2c1b186e68b965bbf466 annotatedProperty IAO_0000115 @default.
- B5fc2e6d4aecf2c1b186e68b965bbf466 annotatedSource NCIT_C106369 @default.
- B5fc2e6d4aecf2c1b186e68b965bbf466 annotatedTarget "The hydrochloride salt form of simmitecan, an ester prodrug of chimmitecan, a 9-alkyl substituted camptothecin derivative with potential antineoplastc activity. Upon intravenous administration, simmitecan is hydrolyzed by carboxylesterase and the activated form, chimmitecan, is produced. Chimmitecan inhibits topoisomerase I, stabilizes covalent topoisomerase I-DNA complexes, and inhibits the religation of topoisomerase I-mediated single-strand DNA breaks. Futhermore, the covalent topoisomerase I-DNA complexes interfere and block the DNA replication machinery, resulting in the production of potentially lethal double-strand DNA breaks. This leads to an inhibition of DNA replication and the induction of apoptosis. The modification at position 9 yields improved cytotoxicity compared to some other camptothecin analogues." @default.