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- B602a1bf65f0d9919a6d7e10d472aa6cb NCIT_P378 "NCI" @default.
- B602a1bf65f0d9919a6d7e10d472aa6cb type Axiom @default.
- B602a1bf65f0d9919a6d7e10d472aa6cb annotatedProperty IAO_0000115 @default.
- B602a1bf65f0d9919a6d7e10d472aa6cb annotatedSource NCIT_C84870 @default.
- B602a1bf65f0d9919a6d7e10d472aa6cb annotatedTarget "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.