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- B603289912ae18e16832f9fb36e308768 NCIT_P378 "NCI" @default.
- B603289912ae18e16832f9fb36e308768 type Axiom @default.
- B603289912ae18e16832f9fb36e308768 annotatedProperty IAO_0000115 @default.
- B603289912ae18e16832f9fb36e308768 annotatedSource NCIT_C1363 @default.
- B603289912ae18e16832f9fb36e308768 annotatedTarget "A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors." @default.