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- B612e9081615849952641c81d3ae49cbc NCIT_P378 "NCI" @default.
- B612e9081615849952641c81d3ae49cbc type Axiom @default.
- B612e9081615849952641c81d3ae49cbc annotatedProperty IAO_0000115 @default.
- B612e9081615849952641c81d3ae49cbc annotatedSource NCIT_C1762 @default.
- B612e9081615849952641c81d3ae49cbc annotatedTarget "The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer." @default.