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- B61345b4da763ea71e81b02e2ee4914f7 NCIT_P378 "NCI" @default.
- B61345b4da763ea71e81b02e2ee4914f7 type Axiom @default.
- B61345b4da763ea71e81b02e2ee4914f7 annotatedProperty IAO_0000115 @default.
- B61345b4da763ea71e81b02e2ee4914f7 annotatedSource NCIT_C1623 @default.
- B61345b4da763ea71e81b02e2ee4914f7 annotatedTarget "A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest." @default.