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- B614ec5039713705dd624304e0024c08e NCIT_P378 "NCI" @default.
- B614ec5039713705dd624304e0024c08e type Axiom @default.
- B614ec5039713705dd624304e0024c08e annotatedProperty IAO_0000115 @default.
- B614ec5039713705dd624304e0024c08e annotatedSource NCIT_C741 @default.
- B614ec5039713705dd624304e0024c08e annotatedTarget "A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation." @default.