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- B61a9ec0de84f38e4c392ee679d2d57c0 NCIT_P378 "NCI" @default.
- B61a9ec0de84f38e4c392ee679d2d57c0 type Axiom @default.
- B61a9ec0de84f38e4c392ee679d2d57c0 annotatedProperty IAO_0000115 @default.
- B61a9ec0de84f38e4c392ee679d2d57c0 annotatedSource NCIT_C107506 @default.
- B61a9ec0de84f38e4c392ee679d2d57c0 annotatedTarget "An orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity. Upon oral administration, tazemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in EZH2 mutated cancer cells. EZH2, which belongs to the class of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of cancer cells and plays a key role in tumor cell proliferation." @default.