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- B61f46124a8b5c3799d306357a07c8bfb NCIT_P378 "NCI" @default.
- B61f46124a8b5c3799d306357a07c8bfb type Axiom @default.
- B61f46124a8b5c3799d306357a07c8bfb annotatedProperty IAO_0000115 @default.
- B61f46124a8b5c3799d306357a07c8bfb annotatedSource NCIT_C1762 @default.
- B61f46124a8b5c3799d306357a07c8bfb annotatedTarget "The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer." @default.