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- B6217ee3dfeca28d2b790ff8e53879528 NCIT_P378 "NCI" @default.
- B6217ee3dfeca28d2b790ff8e53879528 type Axiom @default.
- B6217ee3dfeca28d2b790ff8e53879528 annotatedProperty IAO_0000115 @default.
- B6217ee3dfeca28d2b790ff8e53879528 annotatedSource NCIT_C171629 @default.
- B6217ee3dfeca28d2b790ff8e53879528 annotatedTarget "A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks." @default.