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- B623a440a5da34eea97486598d6ae26b4 NCIT_P378 "NCI" @default.
- B623a440a5da34eea97486598d6ae26b4 type Axiom @default.
- B623a440a5da34eea97486598d6ae26b4 annotatedProperty IAO_0000115 @default.
- B623a440a5da34eea97486598d6ae26b4 annotatedSource NCIT_C29503 @default.
- B623a440a5da34eea97486598d6ae26b4 annotatedTarget "An arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever." @default.