Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B626343bd7d2cd36d54c5bc0eb83bfb15> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B626343bd7d2cd36d54c5bc0eb83bfb15 NCIT_P378 "NCI" @default.
- B626343bd7d2cd36d54c5bc0eb83bfb15 type Axiom @default.
- B626343bd7d2cd36d54c5bc0eb83bfb15 annotatedProperty IAO_0000115 @default.
- B626343bd7d2cd36d54c5bc0eb83bfb15 annotatedSource NCIT_C179621 @default.
- B626343bd7d2cd36d54c5bc0eb83bfb15 annotatedTarget "A preparation of T-lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2) and the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunostimulating and antineoplastic activities. Upon administration, anti-HER2/anti-PD-L1 CAR T-cells target and bind to HER2- and PD-L1-expressing tumor cells, thereby inducing selective toxicity in HER2- and PD-L1-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. PD-L1 is overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity." @default.