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- B62a71c2694c08ffd6f5a8ce267a377b4 NCIT_P378 "NCI" @default.
- B62a71c2694c08ffd6f5a8ce267a377b4 type Axiom @default.
- B62a71c2694c08ffd6f5a8ce267a377b4 annotatedProperty IAO_0000115 @default.
- B62a71c2694c08ffd6f5a8ce267a377b4 annotatedSource NCIT_C81114 @default.
- B62a71c2694c08ffd6f5a8ce267a377b4 annotatedTarget "The tartrate salt form of metyrapone, a pyridine derivative and an inhibitor of steroid 11-beta-hydroxylase with anti-adrenal activity. Metyrapone inhibits steroid 11-beta-hydroxylase, thereby inhibiting the synthesis of cortisol from 11-deoxycortisol, and corticosterone, the precursor of aldosterone, from deoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continued stimulation of the adrenal gland by ACTH results in the accumulation of corticoid precursors, 11-deoxycortisol and deoxycorticosterone. These corticoid precursors are excreted in urine and may be used as indicators for hypothalamic-pituitary ACTH function." @default.