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- B62c590119aa72a72e521c175175c24b4 NCIT_P378 "NCI" @default.
- B62c590119aa72a72e521c175175c24b4 type Axiom @default.
- B62c590119aa72a72e521c175175c24b4 annotatedProperty IAO_0000115 @default.
- B62c590119aa72a72e521c175175c24b4 annotatedSource NCIT_C185590 @default.
- B62c590119aa72a72e521c175175c24b4 annotatedTarget "A preparation of autologous T-lymphocytes engineered to co-express two chimeric antigen receptors (CARs) specific for epidermal growth factor receptor (EGFR) epitope 806 and interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-EGFR/anti-IL13Ra2 CAR T-cells are directed to, bind to, and induce selective toxicity in EGFR deletion mutation variant III (EGFRvIII)-expressing and IL13Ra2-expressing tumor cells. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells. The binding of IL13Ra2 to EGFRvIII upregulates the tyrosine kinase activity of EGFRvIII and promotes tumor cell proliferation." @default.