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- B62e209439244202578def6629d80c9b7 NCIT_P378 "NCI" @default.
- B62e209439244202578def6629d80c9b7 type Axiom @default.
- B62e209439244202578def6629d80c9b7 annotatedProperty IAO_0000115 @default.
- B62e209439244202578def6629d80c9b7 annotatedSource NCIT_C28985 @default.
- B62e209439244202578def6629d80c9b7 annotatedTarget "A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)" @default.