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- B638802aad6d5dfe1cffc37f970de2f45 NCIT_P378 "NCI" @default.
- B638802aad6d5dfe1cffc37f970de2f45 type Axiom @default.
- B638802aad6d5dfe1cffc37f970de2f45 annotatedProperty IAO_0000115 @default.
- B638802aad6d5dfe1cffc37f970de2f45 annotatedSource NCIT_C82676 @default.
- B638802aad6d5dfe1cffc37f970de2f45 annotatedTarget "A liposomal formulation of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell." @default.