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- B638948f338ed28cf73a119f4d6d234d3 NCIT_P378 "NCI" @default.
- B638948f338ed28cf73a119f4d6d234d3 type Axiom @default.
- B638948f338ed28cf73a119f4d6d234d3 annotatedProperty IAO_0000115 @default.
- B638948f338ed28cf73a119f4d6d234d3 annotatedSource NCIT_C73685 @default.
- B638948f338ed28cf73a119f4d6d234d3 annotatedTarget "Chromobox protein homolog 5 (191 aa, ~22 kDa) is encoded by the human CBX5 gene. This soluble, nuclear protein plays a role in epigenetic modification of chromatin, by catalyzing the monomethylation of lysine 5 of histone H2B. The outcome of this modification is associated with either activated gene transcription, or, if further processed to trimethylated lysine 5, epigenetically repressed gene transcription. By affecting the balance of chromatin in heterochromatin and euchromatin at specific gene loci, this protein acts as a candidate tumor suppressor." @default.