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- B63cf61f4877d6eeda059357e363aa24b NCIT_P378 "BIOCARTA" @default.
- B63cf61f4877d6eeda059357e363aa24b type Axiom @default.
- B63cf61f4877d6eeda059357e363aa24b annotatedProperty NCIT_P325 @default.
- B63cf61f4877d6eeda059357e363aa24b annotatedSource NCIT_C39266 @default.
- B63cf61f4877d6eeda059357e363aa24b annotatedTarget "Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB. (This definition may be outdated - see the DesignNote.)" @default.