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- B63dde5d55d7c7c10bc60217d4fe74972 NCIT_P378 "NCI" @default.
- B63dde5d55d7c7c10bc60217d4fe74972 type Axiom @default.
- B63dde5d55d7c7c10bc60217d4fe74972 annotatedProperty IAO_0000115 @default.
- B63dde5d55d7c7c10bc60217d4fe74972 annotatedSource NCIT_C76405 @default.
- B63dde5d55d7c7c10bc60217d4fe74972 annotatedTarget "A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time." @default.