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- B642ef7048fd752b965d26561eacdbf9e NCIT_P378 "NCI" @default.
- B642ef7048fd752b965d26561eacdbf9e type Axiom @default.
- B642ef7048fd752b965d26561eacdbf9e annotatedProperty IAO_0000115 @default.
- B642ef7048fd752b965d26561eacdbf9e annotatedSource NCIT_C661 @default.
- B642ef7048fd752b965d26561eacdbf9e annotatedTarget "A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)" @default.