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- B64636533bff8b866c23417dda8031bea NCIT_P378 "NCI" @default.
- B64636533bff8b866c23417dda8031bea type Axiom @default.
- B64636533bff8b866c23417dda8031bea annotatedProperty IAO_0000115 @default.
- B64636533bff8b866c23417dda8031bea annotatedSource NCIT_C162871 @default.
- B64636533bff8b866c23417dda8031bea annotatedTarget "A recombinant, humanized monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody BAT1306 targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.