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- B64c42da2f31f27c410258649c46e50d7 NCIT_P378 "NCI" @default.
- B64c42da2f31f27c410258649c46e50d7 type Axiom @default.
- B64c42da2f31f27c410258649c46e50d7 annotatedProperty IAO_0000115 @default.
- B64c42da2f31f27c410258649c46e50d7 annotatedSource NCIT_C29078 @default.
- B64c42da2f31f27c410258649c46e50d7 annotatedTarget "A synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions." @default.