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- B65140e6aebfac6aaa8a5bbcda27a2e09 NCIT_P378 "NCI" @default.
- B65140e6aebfac6aaa8a5bbcda27a2e09 type Axiom @default.
- B65140e6aebfac6aaa8a5bbcda27a2e09 annotatedProperty IAO_0000115 @default.
- B65140e6aebfac6aaa8a5bbcda27a2e09 annotatedSource NCIT_C62435 @default.
- B65140e6aebfac6aaa8a5bbcda27a2e09 annotatedTarget "The orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types." @default.