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- B654518c0e6b7272df25aee93e86fd8dc NCIT_P378 "NCI" @default.
- B654518c0e6b7272df25aee93e86fd8dc type Axiom @default.
- B654518c0e6b7272df25aee93e86fd8dc annotatedProperty IAO_0000115 @default.
- B654518c0e6b7272df25aee93e86fd8dc annotatedSource NCIT_C162344 @default.
- B654518c0e6b7272df25aee93e86fd8dc annotatedTarget "A stilbenoid originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 (CA1) promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis; destruction of the tumor vasculature; disruption of tumor blood flow; and tumor cell necrosis. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production." @default.