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- B65568c7687045f7cefc43d9d0afb2a87 NCIT_P378 "NCI" @default.
- B65568c7687045f7cefc43d9d0afb2a87 type Axiom @default.
- B65568c7687045f7cefc43d9d0afb2a87 annotatedProperty IAO_0000115 @default.
- B65568c7687045f7cefc43d9d0afb2a87 annotatedSource NCIT_C235 @default.
- B65568c7687045f7cefc43d9d0afb2a87 annotatedTarget "A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)" @default.