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- B655f91002ff50bfe6afcb745937b736f NCIT_P378 "NCI" @default.
- B655f91002ff50bfe6afcb745937b736f type Axiom @default.
- B655f91002ff50bfe6afcb745937b736f annotatedProperty IAO_0000115 @default.
- B655f91002ff50bfe6afcb745937b736f annotatedSource NCIT_C103274 @default.
- B655f91002ff50bfe6afcb745937b736f annotatedTarget "A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation. Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as a receptor for membrane bound ligands and has various roles during development; dysregulated Notch signaling is associated with increased cell growth and chemoresistance in cancers." @default.