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- B656487dbbe1ae651e1880aa112b321f3 NCIT_P378 "NCI" @default.
- B656487dbbe1ae651e1880aa112b321f3 type Axiom @default.
- B656487dbbe1ae651e1880aa112b321f3 annotatedProperty IAO_0000115 @default.
- B656487dbbe1ae651e1880aa112b321f3 annotatedSource NCIT_C82404 @default.
- B656487dbbe1ae651e1880aa112b321f3 annotatedTarget "A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies." @default.