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- B65bfe5d40bf3a3bff9186f693bf38f8a NCIT_P378 "NCI" @default.
- B65bfe5d40bf3a3bff9186f693bf38f8a type Axiom @default.
- B65bfe5d40bf3a3bff9186f693bf38f8a annotatedProperty IAO_0000115 @default.
- B65bfe5d40bf3a3bff9186f693bf38f8a annotatedSource NCIT_C20986 @default.
- B65bfe5d40bf3a3bff9186f693bf38f8a annotatedTarget "Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins are stable secretory polypeptides expressed in gastrointestinal mucosa that have at least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The exact function has not been determined, but TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition and reducing apoptosis. Strong expression is also found in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155, OMIM 113710, and NCI)" @default.