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- B65f6f3ff9f1e346e4acf03cd529bdd8c NCIT_P378 "NCI" @default.
- B65f6f3ff9f1e346e4acf03cd529bdd8c type Axiom @default.
- B65f6f3ff9f1e346e4acf03cd529bdd8c annotatedProperty IAO_0000115 @default.
- B65f6f3ff9f1e346e4acf03cd529bdd8c annotatedSource NCIT_C62046 @default.
- B65f6f3ff9f1e346e4acf03cd529bdd8c annotatedTarget "A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting." @default.