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- B65fee588045897bd6b38fbcdb02f48a9 NCIT_P378 "NCI" @default.
- B65fee588045897bd6b38fbcdb02f48a9 type Axiom @default.
- B65fee588045897bd6b38fbcdb02f48a9 annotatedProperty IAO_0000115 @default.
- B65fee588045897bd6b38fbcdb02f48a9 annotatedSource NCIT_C80963 @default.
- B65fee588045897bd6b38fbcdb02f48a9 annotatedTarget "The sodium salt form of ditiocarb, an active metabolite of disulfiram, with potential antineoplastic and chemosensitizing activities. Upon administration, ditiocarb sodium may form a complex with copper (Cu), a metal that selectively accumulates in cancer cells. This complex may inhibit the nuclear factor-kB (NF-kB) pathway activated by tumor hypoxia, thereby inhibiting tumor cell growth. It may also reverse chemoresistance and enhance cytotoxicity of other chemotherapeutic agents." @default.