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- B664cdbe64328c594973cd931541963d6 NCIT_P378 "NCI" @default.
- B664cdbe64328c594973cd931541963d6 type Axiom @default.
- B664cdbe64328c594973cd931541963d6 annotatedProperty IAO_0000115 @default.
- B664cdbe64328c594973cd931541963d6 annotatedSource NCIT_C2676 @default.
- B664cdbe64328c594973cd931541963d6 annotatedTarget "A neuroattenuated, replication-competent, recombinant herpes simplex virus-1 (HSV-1) with potential oncolytic activity. Upon intracerebral administration, oncolytic HSV-1 G207 preferentially replicates within glioma cells, which may elicit tumor-specific systemic immune and cytotoxic T lymphocyte (CTL) responses in addition to direct cytopathic effects. Derived from wild-type HSV-1 strain F, this agent has been neuroattenuated by deletions in both copies of the gamma34.5 gene, the major determinant of HSV neurovirulence. In addition, the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), has been inactivated through the insertion of the Escherichia coli lacZ gene. By inactivating UL39, viral ribonucleotide reductase activity is disrupted, resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in nondividing cells but not in dividing cells." @default.