Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B6671a70cd48e6db2943e68ab4aa12dc9> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B6671a70cd48e6db2943e68ab4aa12dc9 NCIT_P378 "NCI" @default.
- B6671a70cd48e6db2943e68ab4aa12dc9 type Axiom @default.
- B6671a70cd48e6db2943e68ab4aa12dc9 annotatedProperty IAO_0000115 @default.
- B6671a70cd48e6db2943e68ab4aa12dc9 annotatedSource NCIT_C1840 @default.
- B6671a70cd48e6db2943e68ab4aa12dc9 annotatedTarget "A benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors." @default.