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- B6693abb618fe50c31f41c11e7cf0afcd NCIT_P378 "NCI" @default.
- B6693abb618fe50c31f41c11e7cf0afcd type Axiom @default.
- B6693abb618fe50c31f41c11e7cf0afcd annotatedProperty IAO_0000115 @default.
- B6693abb618fe50c31f41c11e7cf0afcd annotatedSource NCIT_C788 @default.
- B6693abb618fe50c31f41c11e7cf0afcd annotatedTarget "A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)" @default.