Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B66e856bfdfaa2e5559d9b5a327b41a95> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B66e856bfdfaa2e5559d9b5a327b41a95 NCIT_P378 "NCI" @default.
- B66e856bfdfaa2e5559d9b5a327b41a95 type Axiom @default.
- B66e856bfdfaa2e5559d9b5a327b41a95 annotatedProperty IAO_0000115 @default.
- B66e856bfdfaa2e5559d9b5a327b41a95 annotatedSource NCIT_C116871 @default.
- B66e856bfdfaa2e5559d9b5a327b41a95 annotatedTarget "A semi-synthetic, orally bioavailable, third-generation taxane derivative and microtubule-stabilizing agent, with potential antineoplastic activity. Upon administration, simotaxel binds to tubulin, promotes microtubule assembly and stabilization, and prevents microtubule depolymerization. This results in G2/M arrest, apoptosis and the inhibition of cell proliferation in susceptible tumor cells. This agent is a poor substrate for P-glycoprotein-related drug resistance mechanisms; therefore, it may be useful for treating multi-drug resistant tumors. MST-997 is more potent than paclitaxel and docetaxel and overcomes paclitaxel and docetaxel resistance in certain tumor cell types." @default.