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- B66f8bf2a199604eb41d54a233651bdcd NCIT_P378 "NCI" @default.
- B66f8bf2a199604eb41d54a233651bdcd type Axiom @default.
- B66f8bf2a199604eb41d54a233651bdcd annotatedProperty IAO_0000115 @default.
- B66f8bf2a199604eb41d54a233651bdcd annotatedSource NCIT_C65306 @default.
- B66f8bf2a199604eb41d54a233651bdcd annotatedTarget "A broad-spectrum, fifth-generation, pyrrolidinone cephalosporin with antibacterial activity. Ceftobiprole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.