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- B673b31460ad4832a36a2bd9ae21420d5 NCIT_P378 "NCI" @default.
- B673b31460ad4832a36a2bd9ae21420d5 type Axiom @default.
- B673b31460ad4832a36a2bd9ae21420d5 annotatedProperty IAO_0000115 @default.
- B673b31460ad4832a36a2bd9ae21420d5 annotatedSource NCIT_C1541 @default.
- B673b31460ad4832a36a2bd9ae21420d5 annotatedTarget "A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis." @default.